Pfizer and AstraZeneca have agreed to a major pharmaceutical deal to help pay for the drug's biggest patent loss.
The new US-imposed deal will allow Pfizer to bring the US drug company's blockbuster cholesterol drug Nexium, which will be used to treat heartburn, to a $15 billion market.
The deal, which is expected to be announced at the World Health Organization meeting next month, is the latest attempt by the companies to take on the lucrative drug industry. AstraZeneca's patent for Nexium expires in 2014 and is expected to be worth $30 billion in revenues this year.
The deal marks the latest attempt by Pfizer to extend its top-selling cholesterol drug, the cholesterol pill Nexium, to Europe. The company has already agreed to buy Teva Pharmaceutical Industries Ltd., an Israeli company that makes the drug, for $13.5 billion.
Pfizer's deal will allow Pfizer to bring Nexium to the United States, for an estimated $3.5 billion, with the first-ever generic version expected to be sold in Europe. The company has also said it will sell the version to customers in other countries for up to $13 billion.
The deal, which was announced in April, will be paid for by Pfizer, the world's largest drugmaker, which has about $13.5 billion in revenue, according to Bloomberg. Pfizer also will pay for the marketing and distribution of a new version of the cholesterol drug called L'Oreal, which is based in Germany and is expected to be sold in Europe by the end of the year.
The agreement is expected to be announced at a meeting next month.
Pfizer to acquire US drug company's blockbuster cholesterol drug NexiumL'Orealwill be launched in the US from Nov. 11, 2014. The company also is marketing the drug in Europe, where it will be sold in the UK.
L'Oreal will be launched in the US from Nov. Pfizer is set to pay a $15 billion charge to the US company to help pay for the marketing of the drug. The Pfizer logo is seen on the Pfizer Inc. logoEli Lilly's product line, which will be available to buy through Nov. The company's logo is seen on the company's product line, which will be available through Nov. The logo of Eli Lilly, Inc., a division of Eli Lilly and Co., a division of Lilly and Company, will be on the company's product line, which will be available through Nov. The logo of Eli Lilly, Inc., a division of Eli Lilly and Company, will be on the product line, which will be available through Nov. The logo of Lilly, an international pharmaceutical company, will be on the product line, which will be available through Nov. The logo of Eli Lilly, an international pharmaceutical company, will be on the product line, which will be available through Nov. The company's logo is seen on the product line, which will be available through Nov. Pfizer Inc.'s product line, which will be available through Nov. 11, 2014, will be used to market Nexium.
AstraZeneca to partner with Pfizer in global Nexium marketingPfizer is also expected to buy Teva Pharmaceutical Industries Ltd., for $13.5 billion. Teva is based in Israel and will own the rights to the drug. Teva plans to market the drug in other European countries, including Spain, Italy and Portugal.
Pfizer's deal with Teva will allow the US company to make its own copy of the Nexium patent in a single-bid transaction, and it will also be able to produce the generic version for $13.5 billion in cash. Pfizer shares were up $19.40 on the Nasdaq market.
The deal comes as a major blow to Pfizer. Pfizer is facing a patent expiry on its cholesterol drug Nexium and a patent expiry on its heartburn drug, Prilosec, which would be the biggest one-time purchaser of the drug.
Both companies have been battling to keep their patents in line, but Teva has said that the drugmaker would sell it in the US until 2017 and is looking for a new patent in 2014, which will run until 2015.
What is Reflux?
Reflux is the backflow of acid from the stomach into the gullet (“foodpipe”) which may become inflamed and painful. This may cause you symptoms such as a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation).
Do I get instant relief from taking a Nexium tablet?
Nexium Control is not meant to bring immediate relief. You may need to take the tablets for 2-3 days in a row before you feel better. You must talk to a doctor if you do not feel better or if you feel worse after 14 days.
How much to take• The recommended dose is one tablet a day. • Do not take more than this recommended dose of one tablet (20 mg) a day, even if you don’t feel an improvement immediately. • You may need to take the tablets for 2 or 3 days in a row before your reflux symptoms (for example, heartburn and acid regurgitation) get better. • The treatment length is up to 14 days. • When your reflux symptoms have completely gone you should stop taking this medicine. • If your reflux symptoms get worse or do not improve after taking this medicine for 14 days in a row, you should consult a doctor. If you have persistent or longstanding, frequently recurring symptoms even after treatment with this medicine, you should contact your doctor. Taking this medicine • You can take your tablet at any time of the day either with food or on an empty stomach. • Swallow your tablet whole with half a glass of water. Do not chew or crush the tablet. This is because the tablet contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. It is important not to damage the pellets.
Alternative method of taking this medicine• Put the tablet in a glass of still (non-fizzy) water. Do not use any other liquids. • Stir until the tablet breaks up (the mixture will not be clear) then drink the mixture straight away or within 30 minutes. Always stir the mixture just before drinking it. • To make sure that you have drunk all of the medicine, rinse the glass very well with half a glass of water and drink it. The solid pieces contain the medicine – do not chew or crush them
Please read the patient information leaflet above to get more information as to side effects, precautions of use etc.
Active Ingredients:
Each gastro-resistant tablet contains 20 mg esomeprazole (as magnesium trihydrate)
List of Excipients:
Glycerol monostearate 40-55 HydroxypropylcelluloseHypromellose 2910 (6 mPa-s) Reddish-brown iron oxide (E-172) Yellow iron oxide (E-172)Magnesium stearate Methacrylic acid ethylacrylate copolymer (1: 1) dispersion 30 per cent Cellulose microcrystallineSynthetic Paraffin Macrogol 6000Polysorbate 80 Crospovidone (Type A) Sodium stearyl fumarateSugar spheres (sucrose and maize starch), Talc, Titanium dioxide (E-171) Triethyl citrate
The generic name is esomeprazole. The excipients arelycerol 40-55 and magnesium stearate, Microcrystalline Cellulose, Talc, and microcrystallineTalc(e-171) with iron oxide (E-172) Yellow iron oxide (E-172)Magnesium stearate Methacrylic acid ethylacrylate copolymer (1: 1) dispersion 30 per cent
The list contains excipients only. Not all available patent medicines are suitable for this medicinal product. You can read more about patent treatments on our.
Side EffectsSide effects which occur when any excipients are broken down by the patient are usually mild. Side effects which do not come off are rare and occur only in large percentage (20% or 40% of patients) of patients.
Prescription Required: Yes
$35.95
Prescription RequiredFor most people, a few things can disrupt your body’s ability to metabolize drugs properly. Without a script, you’ll need to take medications regularly, and these changes can make it more difficult to stay on track with your health. Here, we’ll discuss how to properly take NEXIUM® and discuss the pros and cons of different ways to safely take Nexium®.
Nexium® is a brand-name prescription medication used to treat frequent heartburn and acid reflux. It works by blocking the production of a substance in the stomach’s acid secretion, which can lead to frequent and painful heartburn.
Nexium® was approved by the FDA in 2017 and is manufactured by GlaxoSmithKline. Nexium is an acid-reducing drug that is used to treat GERD, a common digestive condition affecting up to 40% of adults in the U. S. It’s typically taken once a day with or without food. Taking it consistently at the same time each day helps maintain proper acid and potassium levels in your body.
Nexium® is also sometimes used to treat acid reflux (heartburn) or gastroesophageal reflux disease (GERD). It can reduce the frequency of stomach acid production, which can make it harder to swallow and more difficult to pass food.
Works on a regular basis
Works on a consistent basis
Can be taken with or without food
Does not cause weight gain
May help with acid reflux and GERD symptoms
Does not work as effectively if taken on an empty stomach
May cause an increased risk of blood clots (such as heart attacks)
May have side effects like nausea, dizziness, and stomach pain
May affect the mood and behavior of people with bipolar disorder
Can cause weight gain and weight loss (dizziness or lightheadedness)
NEXIUM® is taken as needed at a dosage of 1 mg once daily, with or without food. It’s important to follow your doctor’s instructions regarding the duration of your treatment, which may vary based on the condition being treated. Dosage forms are as follows:
Gastroesophageal reflux disease (GERD)
Adults (under 18 years old)
Children (under 18 years old)
The exact dosage that’s prescribed will be determined by your healthcare provider based on your specific needs. Remember that Nexium® is only effective if taken regularly. It may not be suitable if you have certain medical conditions or are taking other medications.
In some cases, your doctor may adjust your Nexium® dosage without warning. This is because Nexium® can cause side effects like chest pain, difficulty breathing, and changes in heart rhythm (arrhythmias). These side effects are usually mild and temporary. However, if you experience chest pain, trouble breathing, difficulty swallowing, or other symptoms that bother you, consult your doctor promptly.
It’s also important to note that Nexium® can also interact with other medications, so it’s crucial to inform your healthcare provider about all the medications you are taking to prevent any potential interactions. Abstaining from other medications or taking Nexium® without warning can also lead to serious complications.
Nexium (Esomeprazole) is a prescription medication that is used to treat gastroesophageal reflux disease (GERD) and other conditions associated with heartburn and acid reflux. It belongs to a class of drugs called proton pump inhibitors (PPIs). Nexium works by decreasing the amount of stomach acid that your body absorbs from your food. It is important to take this medication as directed by your doctor, usually once a day. If you forget to take a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once. Do not take extra medicine to make up for a missed dose.
If you have taken one or more doses of Nexium(Esomeprazole), it is likely that you will not get the full effect of this medication. Therefore, it is important to take the medication as directed by your doctor. If you do not get the full effect, or if you have not been given the correct dose, call your doctor.
Store the medication at room temperature, away from moisture, heat and direct sunlight. Keep the bottle tightly closed and out of reach of children.
ReferencesThis medication should not be used by children or elderly people. It is also not recommended for people with heart disease or other conditions that may be causing acid reflux, such as high blood pressure, congestive heart failure, or liver disease. In addition, this medication may increase the chance of stomach bleeding, especially if taken for a long time. The risk of developing a serious condition like heart attack or stroke increases with increasing age. Therefore, your doctor will be more than likely to recommend this medication to you if you are taking it for a long time or if you have health problems that make it hard to stop taking it. If you are taking this medication, do not stop taking it without talking to your doctor.
If you miss a dose of Nexium (Esomeprazole), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not store outdated or expired medication, or medicines that have expired or damaged.
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